TISSUE TRANSGLUTAMINASE – IgA (TTG)

Clinical Significance

Tissue Transglutaminase (TTG) is an enzyme responsible for protection, prevention and tissue remodelling or repair processes. Anti-tTG antibodies are more sensitive and specific than anti-Gliadin antibodies. Screening for TTG-IgA antibodies is recommended to identify patients at risk for celiac disease. This test detects autoantibodies in the blood that the body produces as part of the immune response. It also aids in monitoring adherence to gluten-free diet in disease confirmed patients.